Glucose uptake-enhancing activity of the ethanolic extract of Dalbergia sissoo (DS) was investigated using dexamethasone induced insulin resistance in mice. DS showed the presence of tannins and flavonoids which chemical constituent may be responsible for activity. Mice were treated with dexamethasone 10 mg/kg for 21 days and effect of DS at the doses of 250 and 500 mg/kg, p.o. on plasma blood glucose level, serum triglyceride level, levels of hepatic antioxidant enzymes (LPO, GSH, SOD and catalase) and body weight were observed. DS 250mg/kg, p.o. showed less significant (p < 0.05), while 500mg/kg, p.o. showed significant (p < 0.01) decrease in plasma glucose and serum triglyceride levels. The levels of antioxidant enzymes GSH, SOD, and catalase were significantly increased (p < 0.01) and there was significant decrease (p < 0.01) in level of LPO. In conclusion, Dalbergia sissoo may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance.
Loading....